Our laboratory develops novel affinity reagents, primarily for neuroscience research, in the form of recombinant monoclonal antibodies and camelid nanobodies, and engineered derivatives thereof. Our approach to affinity reagents development, validation and use is highly-integrative and multi-scale. The techniques we use employ binder development coupled with extensive validation as intrabodies and as immunolabels and protein capture reagents, focusing on targets of importance to neuroscience including the BRAIN Initiative.  Our recent efforts have focused on development of intrabodies for delivering cargo to specific subcellular sites in brain neurons, and developing nanoscale immunolabels with enhanced penetration and resolution for imaging studies including of intact brains including human. This includes protein production, immunization phage display, ELISAs, immunohistochemistry and imaging including super resolution, confocal, and total internal reflection fluorescence microscopy, and binder engineering.

The Trimmer lab has an outstanding record training academic and industry scientists. A list of recent trainees and their current positions can be found here.

We pride ourselves for promoting a healthy work-life balance that is critical for creative scientific work. Davis is perfect for this, as it is a fun, family friendly city nestled near Sacramento, northern California wine country (Napa and Sonoma), San Francisco, and Lake Tahoe.

The Trimmer lab is in the Department of Physiology and Membrane Biology of UC Davis’ School of Medicine. UC Davis has outstanding core facilities and resources.

We are seeking creative, independent, and collaborative scientists. The applicant should possess a PhD, MD, or equivalent. Preferred qualifications include experience in affinity reagent development and validation, and/or brain imaging. Interested applicants should send an email with a curriculum vitae to James Trimmer at jtrimmer@ucdavis.edu.